Labetalol HCL

A to Z Drug Facts

Labetalol HCL

  Action
  Indications
  Contraindications
  Route/Dosage
  Interactions
  Lab Test Interferences
  Adverse Reactions
  Precautions
Patient Care Considerations
  Administration/Storage
  Assessment/Interventions
  Patient/Family Education


(la-BET-uh-lahl HIGH-droe-KLOR-ide)
Normodyne, Trandate
Class: Alpha-adrenergic blocker/beta-adrenergic blocker

 Action Selectively blocks alpha-1 receptors and nonselectively blocks beta-receptors to decrease BP, heart rate and myocardial oxygen demand.

 Indications Management of hypertension. Unlabeled use(s): Treatment of pheochromocytoma; management of clonidine-withdrawal hypertension.

 Contraindications Severe bradycardia; second- and third-degree heart block; heart failure; cardiogenic shock; bronchial asthma.

 Route/Dosage

ADULTS: PO 100 mg bid initially; maintenance dose usually 200 to 400 mg bid. IV 20 mg over 2 min; then 40 to 80 mg q 10 min up to maximum of 300 mg. Infusions of 2 mg/min can be initiated and titrated to response.

 Interactions

Beta-adrenergic agonists: Blunted bronchodilator effect. Cimetidine: Increased bioavailability of labetalol. Indomethacin: Impaired antihypertensive effect of labetalol. Inhalation anesthetics: May exaggerate hypotension. Nitroglycerin: Increased hypotension. INCOMPATABILITIES: Injection not compatible with 5% sodium bicarbonate.

 Lab Test Interferences Drug may cause false-positive increases in levels of urinary catecholamines.

 Adverse Reactions

CV: Orthostatic hypotension; edema; flushing; ventricular arrhythmias; atrioventricular block; bradycardia; heart failure; chest pain. CNS: Headache; fatigue; dizziness; depression; lethargy; drowsiness; forgetfulness; sleepiness; vertigo; paresthesias; nightmares. DERM: Tingling of scalp; rash; facial erythema; alopecia; urticaria; pruritus; increased sweating. EENT: Dry eyes; visual disturbances; altered taste perception. GI: Nausea; vomiting; diarrhea; dyspepsia. GU: Impotence; urinary retention; difficulty with urination; failure to ejaculate; priapism; Peyronie's disease. HEMA: Leukopenia. HEPA: Elevated transaminases; jaundice; cholestasis. META: Increases or decreases in serum glucose; increased creatinine and BUN. RESP: Bronchospasm; shortness of breath; wheezing. OTHER: Muscle cramps; systemic lupus erythematosus; increased hypoglycemic response to insulin; masking of hypoglycemic signs; asthenia.

 Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Special risk patients: Use drug with caution in patients with diabetes mellitus, CHF, respiratory difficulties or severely elevated BP. Cardiac failure: Has been observed in patients with or without history of cardiac failure. Withdrawal: Do not discontinue abruptly. Abrupt discontinuation may worsen angina and precipitate ischemic event in susceptible individuals.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

OVERDOSAGE: SIGNS & SYMPTOMS
  Excessive orthostatic hypotension, excessive bradycardia, cardiac failure, bronchospasm, seizures

 Patient/Family Education

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© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts